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【结 构 式】 
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【分子编号】31421 【品名】methyl (2S)-3-(4-[6-(benzyloxy)-3-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-1-benzothiophen-2-yl]phenoxy)-2-(tritylamino)propanoate 【CA登记号】 |
【 分 子 式 】C57H54N2O5S 【 分 子 量 】879.13224 【元素组成】C 77.88% H 6.19% N 3.19% O 9.1% S 3.65% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVI)Subsequent Mitsunobu condensation of (XIV) with N-trityl-L-serine methyl ester (XV) in the presence of DEAD and PPh3 produced the serine ether (XVI). Deprotection of the trityl group of (XVI) by means of trifluoroacetic acid and triethylsilane, followed by transfer hydrogenolysis of the benzyl ether with ammonium formate and Pd/C provided the deprotected intermediate (XVII). Finally, reduction of the ester group of (XVII) with LiAlH4 yielded the title compound.
| 【1】 Antithrombotic diamines. EP 0863755; US 6025382; WO 9725033 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIV) | 31419 | 4-[6-(benzyloxy)-3-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-1-benzothiophen-2-yl]phenol | C34H33NO3S | 详情 | 详情 | |
| (XV) | 31420 | methyl (2S)-3-hydroxy-2-(tritylamino)propanoate | C23H23NO3 | 详情 | 详情 | |
| (XVI) | 31421 | methyl (2S)-3-(4-[6-(benzyloxy)-3-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-1-benzothiophen-2-yl]phenoxy)-2-(tritylamino)propanoate | C57H54N2O5S | 详情 | 详情 | |
| (XVII) | 31422 | (2S)-3-amino-2-[(phenylsulfonyl)amino]propionic acid | C9H12N2O4S | 详情 | 详情 |
Extended Information