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【结 构 式】

【分子编号】31303

【品名】5,8-isoquinolinediamine; 5-amino-8-isoquinolinylamine

【CA登记号】

【 分 子 式 】C9H9N3

【 分 子 量 】159.19068

【元素组成】C 67.91% H 5.7% N 26.4%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Treatment of 5-nitroisoquinoline (I) with hydroxylamine and KOH produced 5-nitro-8-aminoisoquinoline (II). Subsequent hydrogenation of (II) over Pd/C gave diamine (III), which was then oxidized to the dichloroquinone (IV) by means potassium chlorate and concentrated HCl. Finally, displacement of the 7-chloro atom of (IV) with p-anisidine (V) in refluxing EtOH yielded the title compound.

1 Ryu, C.-K.; Jung, S.-H.; Lee, C.-O.; Lee, I.-K.; Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8-isoquinolinediones. Bioorg Med Chem Lett 1999, 9, 8, 1075.
2 Ryu, C.-K.; Jung, S.-H.; Lee, I.-K.; et al.; 7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines. Med Chem Res 2000, 10, 1, 40.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 22802 5-nitroisoquinoline 607-32-9 C9H6N2O2 详情 详情
(II) 31302 5-nitro-8-isoquinolinylamine; 5-nitro-8-isoquinolinamine C9H7N3O2 详情 详情
(III) 31303 5,8-isoquinolinediamine; 5-amino-8-isoquinolinylamine C9H9N3 详情 详情
(IV) 31304 6,7-dichloro-5,8-isoquinolinedione C9H3Cl2NO2 详情 详情
(V) 10478 p-Anisidine; 4-Methoxyaniline; 4-Methoxyphenylamine 104-94-9 C7H9NO 详情 详情
Extended Information