|
【结 构 式】 
|
【药物名称】 【化学名称】6-Chloro-7-(4-methoxyphenylamino)isoquinoline-5,8-dione 【CA登记号】 【 分 子 式 】C16H11ClN2O3 【 分 子 量 】314.73067 |
【开发单位】Ewha Womans University (Originator), Korea Res. Inst. Chem. Technol. (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
Treatment of 5-nitroisoquinoline (I) with hydroxylamine and KOH produced 5-nitro-8-aminoisoquinoline (II). Subsequent hydrogenation of (II) over Pd/C gave diamine (III), which was then oxidized to the dichloroquinone (IV) by means potassium chlorate and concentrated HCl. Finally, displacement of the 7-chloro atom of (IV) with p-anisidine (V) in refluxing EtOH yielded the title compound.
| 【1】 Ryu, C.-K.; Jung, S.-H.; Lee, C.-O.; Lee, I.-K.; Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8-isoquinolinediones. Bioorg Med Chem Lett 1999, 9, 8, 1075. |
| 【2】 Ryu, C.-K.; Jung, S.-H.; Lee, I.-K.; et al.; 7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines. Med Chem Res 2000, 10, 1, 40. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22802 | 5-nitroisoquinoline | 607-32-9 | C9H6N2O2 | 详情 | 详情 |
| (II) | 31302 | 5-nitro-8-isoquinolinylamine; 5-nitro-8-isoquinolinamine | C9H7N3O2 | 详情 | 详情 | |
| (III) | 31303 | 5,8-isoquinolinediamine; 5-amino-8-isoquinolinylamine | C9H9N3 | 详情 | 详情 | |
| (IV) | 31304 | 6,7-dichloro-5,8-isoquinolinedione | C9H3Cl2NO2 | 详情 | 详情 | |
| (V) | 10478 | p-Anisidine; 4-Methoxyaniline; 4-Methoxyphenylamine | 104-94-9 | C7H9NO | 详情 | 详情 |
Extended Information