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【结 构 式】 
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【分子编号】31262 【品名】diethyl [bis(2-hydroxyethyl)phosphoryl](cycloheptylamino)methylphosphonate 【CA登记号】 |
【 分 子 式 】C16H35NO6P2 【 分 子 量 】399.404564 【元素组成】C 48.12% H 8.83% N 3.51% O 24.03% P 15.51% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The reaction of cycloheptylamine (I) with triethyl orthoformate (II) and diethyl phosphite (III) at 150 gives cycloheptylaminomethylenediphosphonic acid tetraethyl ester (IV), which is then hydrolyzed with refluxing concentrated hydrochloric acid.
| 【1】 Isomura, Y.; Takeuchi, M.; Sakamoto, S.; Abe, T. (Yamanouchi Pharmaceutical Co., Ltd.); (Cycloalkylamino)methylenebisphosphonic acids and medicines containing them. AU 8928670; EP 0325482; JP 1989308290; US 5041428 . |
| 【2】 Takeuchi, M.; Sakamoto, S.; Kawamuki, K.; Kudo, M.; Murase, K.; Kawashima, H.; Isomura, Y.; Synthesis and structure-activity relationships of a novel anti-resorptive agent YM175, and the related derivatives. Symp Med Chem 1990, P-12. |
| 【3】 Prous, J.; Castaner, J.; YM-175. Drugs Fut 1992, 17, 4, 293. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22234 | cycloheptanamine; cycloheptylamine | 5452-35-7 | C7H15N | 详情 | 详情 |
| (II) | 21304 | Triethyl orthoformate; 1-(Diethoxymethoxy)ethane; Diethoxymethyl ethyl ether | 122-51-0 | C7H16O3 | 详情 | 详情 |
| (III) | 12714 | diethyl phosphonate; diethyl phosphite | 762-04-9 | C4H11O3P | 详情 | 详情 |
| (IV) | 31262 | diethyl [bis(2-hydroxyethyl)phosphoryl](cycloheptylamino)methylphosphonate | C16H35NO6P2 | 详情 | 详情 |
Extended Information