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【结 构 式】

【分子编号】31237

【品名】4,5-bis(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazole; 4-[4-(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazol-5-yl]phenyl methyl ether

【CA登记号】

【 分 子 式 】C21H18N2O2S

【 分 子 量 】362.4522

【元素组成】C 69.59% H 5.01% N 7.73% O 8.83% S 8.85%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The cyclization of alpha-bromo-4,4'-dimethoxidesoxybenzoin (I) with pyrrole-2-carbothioamide (II) in hot acetonitrile gives 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazole (III), which is then condensed with ethyl bromoacetate (IV) by means of NaOH and tetrabutylammonium bromide in refluxing dichloromethane - water.

1 Yoshino, K.; Seko, N.; Yokota, K.; Ito, K.; Tsukamoto, G. (Kanebo Pharmaceuticals, Ltd.); Novel 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazoles, process for the preparation thereof and pharmaceutical compsn. containing the same. EP 0159677; JP 1985222481; JP 1986033186; JP 1986200985; US 4659726 .
2 Prous, J.; Castaner, J.; KBT-3022. Drugs Fut 1991, 16, 2, 105.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 31235 2-bromo-1,2-bis(4-methoxyphenyl)-1-ethanone C16H15BrO3 详情 详情
(II) 31236 1H-pyrrole-2-carbothioamide C5H6N2S 详情 详情
(III) 31237 4,5-bis(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazole; 4-[4-(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazol-5-yl]phenyl methyl ether C21H18N2O2S 详情 详情
(IV) 16640 Ethyl 2-bromoacetate; Ethyl bromoacetate 105-36-2 C4H7BrO2 详情 详情
Extended Information