4,5-bis(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazole; 4-[4-(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazol-5-yl]phenyl methyl ether -Drug Synthesis Database

【结构式】

【分子编号】31237

【品名】4,5-bis(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazole; 4-[4-(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazol-5-yl]phenyl methyl ether

【CA登记号】

【分子式】C₂₁H₁₈N₂O₂S

【分子量】362.4522

【元素组成】C 69.59% H 5.01% N 7.73% O 8.83% S 8.85%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The cyclization of alpha-bromo-4,4'-dimethoxidesoxybenzoin (I) with pyrrole-2-carbothioamide (II) in hot acetonitrile gives 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazole (III), which is then condensed with ethyl bromoacetate (IV) by means of NaOH and tetrabutylammonium bromide in refluxing dichloromethane - water.

参考文献中间体

合成目标

【1】 Yoshino, K.; Seko, N.; Yokota, K.; Ito, K.; Tsukamoto, G. (Kanebo Pharmaceuticals, Ltd.); Novel 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazoles, process for the preparation thereof and pharmaceutical compsn. containing the same. EP 0159677; JP 1985222481; JP 1986033186; JP 1986200985; US 4659726 .
【2】 Prous, J.; Castaner, J.; KBT-3022. Drugs Fut 1991, 16, 2, 105.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	31235	2-bromo-1,2-bis(4-methoxyphenyl)-1-ethanone		C₁₆H₁₅BrO₃	详情	详情
(II)	31236	1H-pyrrole-2-carbothioamide		C₅H₆N₂S	详情	详情
(III)	31237	4,5-bis(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazole; 4-[4-(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazol-5-yl]phenyl methyl ether		C₂₁H₁₈N₂O₂S	详情	详情
(IV)	16640	Ethyl 2-bromoacetate; Ethyl bromoacetate	105-36-2	C₄H₇BrO₂	详情	详情

Extended Information