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【结 构 式】 
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【分子编号】31235 【品名】2-bromo-1,2-bis(4-methoxyphenyl)-1-ethanone 【CA登记号】 |
【 分 子 式 】C16H15BrO3 【 分 子 量 】335.1973 【元素组成】C 57.33% H 4.51% Br 23.84% O 14.32% |
合成路线1
该中间体在本合成路线中的序号：(IV)The amonolysis of trifluoroacetonitrile (I) in refluxing liquid ammonia gives trifluoroacetamidine (II), which by reaction with SH2 in ether is converted into trifluorothioacetamide (III). Finally, this compound is cyclized with p-methoxy-alpha-bromo-alpha-(p-methoxyphenyl)acetophenone (IV) in refluxing acetonitrile.
| 【1】 Rynbrandt, R.H.; Nishizawa, E.E.; US 4168315 . |
| 【2】 Serradell, M.N.; Castaner, J.; Blancafort, P.; TFT. Drugs Fut 1982, 7, 5, 323. |
合成路线2
该中间体在本合成路线中的序号：(I)The cyclization of alpha-bromo-4,4'-dimethoxidesoxybenzoin (I) with pyrrole-2-carbothioamide (II) in hot acetonitrile gives 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazole (III), which is then condensed with ethyl bromoacetate (IV) by means of NaOH and tetrabutylammonium bromide in refluxing dichloromethane - water.
| 【1】 Yoshino, K.; Seko, N.; Yokota, K.; Ito, K.; Tsukamoto, G. (Kanebo Pharmaceuticals, Ltd.); Novel 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazoles, process for the preparation thereof and pharmaceutical compsn. containing the same. EP 0159677; JP 1985222481; JP 1986033186; JP 1986200985; US 4659726 . |
| 【2】 Prous, J.; Castaner, J.; KBT-3022. Drugs Fut 1991, 16, 2, 105. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31235 | 2-bromo-1,2-bis(4-methoxyphenyl)-1-ethanone | C16H15BrO3 | 详情 | 详情 | |
| (II) | 31236 | 1H-pyrrole-2-carbothioamide | C5H6N2S | 详情 | 详情 | |
| (III) | 31237 | 4,5-bis(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazole; 4-[4-(4-methoxyphenyl)-2-(1H-pyrrol-2-yl)-1,3-thiazol-5-yl]phenyl methyl ether | C21H18N2O2S | 详情 | 详情 | |
| (IV) | 16640 | Ethyl 2-bromoacetate; Ethyl bromoacetate | 105-36-2 | C4H7BrO2 | 详情 | 详情 |