5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone -Drug Synthesis Database

【结构式】

【分子编号】31100

【品名】5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone

【CA登记号】

【分子式】C₁₃H₁₅ClO₃

【分子量】254.713

【元素组成】C 61.3% H 5.94% Cl 13.92% O 18.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of 5-hydroxy-7-tetralone (I) with epichlorohydrin (I) at reflux temperature gives 5-(3-chloro-2-hydroxypropoxy)-7-tetralone (III), which is then condensed with butylamine (IV) in refluxlng alcohol.

参考文献中间体

合成目标

【1】 Shavel, J.Jr.; Farber, S. (Pfizer Inc.); 3,4-Dihydroxynaphtalenoneoxy-2-hydroxypropylamines. BE 0739195; DE 1948144; DE 1967162; FR 2018626; GB 1223527; JP 48043734B; US 3641152 .
【2】 Castaner, J.; Serradell, M.N.; Weetman, D.F.; Blancafort, P.; Levobunolol Hydrochloride. Drugs Fut 1983, 8, 9, 788.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	31099	5-hydroxy-3,4-dihydro-1(2H)-naphthalenone	28315-93-7	C₁₀H₁₀O₂	详情	详情
(II)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(III)	31100	5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone		C₁₃H₁₅ClO₃	详情	详情
(IV)	17895	2-Amino-2-methylpropane; tert-butylamine; 2-methyl-2-propanamine	75-64-9	C₄H₁₁N	详情	详情

Extended Information