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【结 构 式】

【分子编号】31099

【品名】5-hydroxy-3,4-dihydro-1(2H)-naphthalenone

【CA登记号】28315-93-7

【 分 子 式 】C10H10O2

【 分 子 量 】162.1882

【元素组成】C 74.06% H 6.21% O 19.73%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The reaction of 5-hydroxy-7-tetralone (I) with epichlorohydrin (I) at reflux temperature gives 5-(3-chloro-2-hydroxypropoxy)-7-tetralone (III), which is then condensed with butylamine (IV) in refluxlng alcohol.

1 Shavel, J.Jr.; Farber, S. (Pfizer Inc.); 3,4-Dihydroxynaphtalenoneoxy-2-hydroxypropylamines. BE 0739195; DE 1948144; DE 1967162; FR 2018626; GB 1223527; JP 48043734B; US 3641152 .
2 Castaner, J.; Serradell, M.N.; Weetman, D.F.; Blancafort, P.; Levobunolol Hydrochloride. Drugs Fut 1983, 8, 9, 788.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 31099 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone 28315-93-7 C10H10O2 详情 详情
(II) 10146 Epichlorohydrin; 2-(Chloromethyl)oxirane 106-89-8 C3H5ClO 详情 详情
(III) 31100 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone C13H15ClO3 详情 详情
(IV) 17895 2-Amino-2-methylpropane; tert-butylamine; 2-methyl-2-propanamine 75-64-9 C4H11N 详情 详情
Extended Information