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【结 构 式】 
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【分子编号】31093 【品名】2-chloro-1-(2,4-dichlorophenyl)-1-ethanol 【CA登记号】13692-14-3 |
【 分 子 式 】C8H7Cl3O 【 分 子 量 】225.50108 【元素组成】C 42.61% H 3.13% Cl 47.17% O 7.1% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The reduction of 2,4-dichlorophenacyl chloride with NaBH4 gives 1-(2,4-dichlorophenyl)-2-chloroethanol (II), which is condensed with imidazole (III) to yield 1-(2,4-dichlorophenyl)-2-(N-imidazolyl)ethanol (IV). Finally, this compound is condensed with 4-(phenylthio)benzyl chloride (V) [prepared by chloromethylation of diphenyl sulfide (VI) with formaldehyde and HCl] using NaH as condensing agent.
| 【1】 Cova, A.; Tajana, A.; Nardi, D.; Cappelleti, R.; Sibilia, C.; Physico-chemical, structural and analytical studies on fenticonazole, a new drug with antimycotic properties. Arzneim-Forsch Drug Res 1981, 31, 12, 2127. |
| 【2】 Nardi, D.; Massarani, E.; Tajana, A.; Veronese, M. (Recordati Industria Chimica e Farmaceutica SpA); Substituted dibenzyl ethers and parmaceutical compositions containing said ethers for the treatment of infections. DE 2917244; FR 2426047; GB 2025395; US 4221803 . |
| 【3】 Blancafort, P.; Castaner, J.; Serradell, M.N.; Fenticonazole Nitrate. Drugs Fut 1983, 8, 9, 767. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31092 | 2,2',4'-trichloroacetophenone; 2-chloro-1-(2,4-dichlorophenyl)-1-ethanone | 4252-78-2 | C8H5Cl3O | 详情 | 详情 |
| (II) | 31093 | 2-chloro-1-(2,4-dichlorophenyl)-1-ethanol | 13692-14-3 | C8H7Cl3O | 详情 | 详情 |
| (III) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
| (IV) | 14550 | 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-1-ethanol; alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol; 1-(2',4'-Dichlorophenyl)-2-(1-imidazolyl)ethanol | 24155-42-8 | C11H10Cl2N2O | 详情 | 详情 |
| (V) | 31094 | 1-(chloromethyl)-4-(phenylsulfanyl)benzene; 4-(chloromethyl)phenyl phenyl sulfide | C13H11ClS | 详情 | 详情 | |
| (VI) | 23188 | 1-(phenylsulfanyl)benzene; diphenyl sulfide | 139-66-2 | C12H10S | 详情 | 详情 |
Extended Information