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【结 构 式】

【分子编号】30814

【品名】tert-butyl (1S)-1-([[(4-methoxybenzyl)oxy]amino]carbonyl)-3-(methylsulfanyl)propylcarbamate

【CA登记号】

【 分 子 式 】C18H28N2O5S

【 分 子 量 】384.4968

【元素组成】C 56.23% H 7.34% N 7.29% O 20.81% S 8.34%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation between N-Boc-methionine (I) and O-(4-methoxybenzyl)hydroxylamine hydrochloride (II) gave the hydroxamate (III), which was then coupled with 2',3'-isopropylideneadenosine (IV) under Mitsunobu conditions to provide adduct (V). Subsequent deprotection with trifluoroacetic acid and anisole yielded the title compound.

1 Kang, M.K.; Kang, S.U.; Kim, S.; Chun, M.W.; Jo, Y.J.; Kwak, J.H.; Lee, J.; Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase. Bioorg Med Chem Lett 1999, 9, 10, 1365.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 26710 (2R)-2-[(tert-butoxycarbonyl)amino]-4-(methylsulfanyl)butyric acid 5241-66-7 C10H19NO4S 详情 详情
(II) 30813 1-[(aminooxy)methyl]-4-methoxybenzene; O-(4-methoxybenzyl)hydroxylamine C8H11NO2 详情 详情
(III) 30814 tert-butyl (1S)-1-([[(4-methoxybenzyl)oxy]amino]carbonyl)-3-(methylsulfanyl)propylcarbamate C18H28N2O5S 详情 详情
(IV) 17560 [(3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methanol 362-75-4 C13H17N5O4 详情 详情
(V) 30815 tert-butyl (1S)-1-([[[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl][(4-methoxybenzyl)oxy]amino]carbonyl)-3-(methylsulfanyl)propylcarbamate C31H43N7O8S 详情 详情
Extended Information