【结 构 式】 |
【分子编号】30814 【品名】tert-butyl (1S)-1-([[(4-methoxybenzyl)oxy]amino]carbonyl)-3-(methylsulfanyl)propylcarbamate 【CA登记号】 |
【 分 子 式 】C18H28N2O5S 【 分 子 量 】384.4968 【元素组成】C 56.23% H 7.34% N 7.29% O 20.81% S 8.34% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The condensation between N-Boc-methionine (I) and O-(4-methoxybenzyl)hydroxylamine hydrochloride (II) gave the hydroxamate (III), which was then coupled with 2',3'-isopropylideneadenosine (IV) under Mitsunobu conditions to provide adduct (V). Subsequent deprotection with trifluoroacetic acid and anisole yielded the title compound.
【1】 Kang, M.K.; Kang, S.U.; Kim, S.; Chun, M.W.; Jo, Y.J.; Kwak, J.H.; Lee, J.; Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase. Bioorg Med Chem Lett 1999, 9, 10, 1365. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 26710 | (2R)-2-[(tert-butoxycarbonyl)amino]-4-(methylsulfanyl)butyric acid | 5241-66-7 | C10H19NO4S | 详情 | 详情 |
(II) | 30813 | 1-[(aminooxy)methyl]-4-methoxybenzene; O-(4-methoxybenzyl)hydroxylamine | C8H11NO2 | 详情 | 详情 | |
(III) | 30814 | tert-butyl (1S)-1-([[(4-methoxybenzyl)oxy]amino]carbonyl)-3-(methylsulfanyl)propylcarbamate | C18H28N2O5S | 详情 | 详情 | |
(IV) | 17560 | [(3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methanol | 362-75-4 | C13H17N5O4 | 详情 | 详情 |
(V) | 30815 | tert-butyl (1S)-1-([[[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl][(4-methoxybenzyl)oxy]amino]carbonyl)-3-(methylsulfanyl)propylcarbamate | C31H43N7O8S | 详情 | 详情 |
Extended Information