[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(methylsulfanyl)butanoate -Drug Synthesis Database

【结构式】

【分子编号】30812

【品名】[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(methylsulfanyl)butanoate

【CA登记号】

【分子式】C₂₃H₃₄N₆O₇S

【分子量】538.6252

【元素组成】C 51.29% H 6.36% N 15.6% O 20.79% S 5.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Coupling of 2',3'-isopropylideneadenosine (I) with N-Boc-methionine (II) by means of DCC provided ester (III). Subsequent deprotection of (III) under acidic conditions yielded the title compound.

参考文献中间体

合成目标

【1】 Kang, M.K.; Kang, S.U.; Kim, S.; Chun, M.W.; Jo, Y.J.; Kwak, J.H.; Lee, J.; Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase. Bioorg Med Chem Lett 1999, 9, 10, 1365.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	17560	[(3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methanol	362-75-4	C₁₃H₁₇N₅O₄	详情	详情
(II)	26710	(2R)-2-[(tert-butoxycarbonyl)amino]-4-(methylsulfanyl)butyric acid	5241-66-7	C₁₀H₁₉NO₄S	详情	详情
(III)	30812	[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(methylsulfanyl)butanoate		C₂₃H₃₄N₆O₇S	详情	详情

Extended Information