1,1,1-trichloroethane -Drug Synthesis Database

【结构式】

【分子编号】30737

【品名】1,1,1-trichloroethane

【CA登记号】71-55-6

【分子式】C₂H₃Cl₃

【分子量】133.40392

【元素组成】C 18.01% H 2.27% Cl 79.73%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

A new method for the synthesis of malotilate has been reported: The reaction of diisopropylmalonate (I) with carbon disulfide (II) by means of KOH in DMSO gives the dipotassium salt of diisopropyl dithiolylidene-malonate (III), which is then cyclized with 1,1,1-trichloroethane (IV) by means of KOH in the same solvent as before.

参考文献中间体

合成目标

【1】 Matsui, H.; Tanaka, H.; Yabutani, K.; Kurono, H. (Nihon Nohyaku Co., Ltd.); Process for producing 1,3-dithiol-2-ylidene malonates. US 4327223 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30735	diisopropyl malonate	13195-64-7	C₉H₁₆O₄	详情	详情
(III)	30736	dipotassium 3-isopropoxy-2-(isopropoxycarbonyl)-3-oxo-1-propene-1,1-dithiolate		C₁₀H₁₄K₂O₄S₂	详情	详情
(IV)	30737	1,1,1-trichloroethane	71-55-6	C₂H₃Cl₃	详情	详情

Extended Information