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【结 构 式】 
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【分子编号】30735 【品名】diisopropyl malonate 【CA登记号】13195-64-7 |
【 分 子 式 】C9H16O4 【 分 子 量 】188.22364 【元素组成】C 57.43% H 8.57% O 34% |
合成路线1
该中间体在本合成路线中的序号：(I)A new method for the synthesis of malotilate has been reported: The reaction of diisopropylmalonate (I) with carbon disulfide (II) by means of KOH in DMSO gives the dipotassium salt of diisopropyl dithiolylidene-malonate (III), which is then cyclized with 1,1,1-trichloroethane (IV) by means of KOH in the same solvent as before.
| 【1】 Matsui, H.; Tanaka, H.; Yabutani, K.; Kurono, H. (Nihon Nohyaku Co., Ltd.); Process for producing 1,3-dithiol-2-ylidene malonates. US 4327223 . |
合成路线2
该中间体在本合成路线中的序号：(III)This compound can be obtained by several related ways: 1) The reaction of 2-thioxo-1,3-dithiole-4,5-dicarboxylic acid (I) with methyl iodide in refluxing nitromethane gives 2-(methylsulfanyl)-1,3-dithiolium iodide (II), which is finally condensed with diisopropyl malonate (III), by means of NaH in refluxing THF. 2) The cyclization of sodium acetylide (IV) with sulfur and carbon disulfide gives 1,3-dithiole-2-thione (V), which is treated first with dimethyl sulfate and then with sodium perchlorate yielding 2-(methylsulfanyl)-1,3-dithiolium perchlorate (V). Finally, this compound is condensed with diisopropyl malonate (III) by means of NaH as before. 3) 1,3-Dithiole-2-thione (V) can also be obtained by cyclization of ethylene carbonate (VII) with carbon disulfide by means of K2CO3 and hexabutyldistannathiane. 4) 1,3-Dithiole-2-thione (V) can also be obtained by cyclization of ethylene trithiocarbonate (VIII) with acetylene at 110-45 C, although with low yields. 5) The selective hydrolysis of 2-(4-acetoxy-1,3-dithiol-2-ylidene)malonic acid diisopropyl ester (IX) gives the corresponding 4-hydroxy derivative (X), which is finally dehydrated with either, chlorosulfonic acid or sulfuric acid or thionyl chloride and DBU or phosphorous trichloride or phosphorous oxychloride.
| 【1】 Fujinami, T.; et al.; The preparation of cyclic dithia and thiaza compounds by the reaction of potassium carbonate with heterocumulenes and alkylene dibromides or carbonate catalyzed by organostannyl compounds. Bull Chem Soc Jpn 1982, 55, 4, 1174. |
| 【2】 Mayer, R.; et al.; Synthesis of 1,3-dithiol-2-thiones (' Isotrithione'). Angew Chem. Int Ed Engl 1964, 76, 3, 143. |
| 【3】 Jones, F.N.; O'Connor, B.R.; Reactions of ethylene di- and trithiocarbonates with acetylenes. Anomalous reaction with bromocyanoacetylene to give a thioacyl bromide. J Org Chem 1970, 35, 6, 2002. |
| 【4】 Kurono, H.; Hirano, A.; Taninaka, K. (Nihon Nohyaku Co., Ltd.); 1,3-Dithiol-2-ylidene malonic esters. DE 2545569; US 4035387 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 23634 | acetylene | 74-86-2 | C2H2 | 详情 | 详情 | |
| (I) | 34902 | 2-thioxo-1,3-dithiole-4,5-dicarboxylic acid | C5H2O4S3 | 详情 | 详情 | |
| (II) | 34903 | 1,3-dithiol-2-ylidene(methyl)sulfonium iodide | C4H5IS3 | 详情 | 详情 | |
| (III) | 30735 | diisopropyl malonate | 13195-64-7 | C9H16O4 | 详情 | 详情 |
| (IV) | 34904 | ethynylsodium | 1066-26-8 | C2HNa | 详情 | 详情 |
| (V) | 34905 | 1,3-dithiole-2-thione | 930-35-8 | C3H2S3 | 详情 | 详情 |
| (VI) | 34906 | 1,3-dithiol-2-ylidene(methyl)sulfonium perchlorate | C4H5ClO4S3 | 详情 | 详情 | |
| (VII) | 32802 | 1,3-dioxolan-2-one | 96-49-1 | C3H4O3 | 详情 | 详情 |
| (VIII) | 34907 | 1,3-dithiolane-2-thione | 822-38-8 | C3H4S3 | 详情 | 详情 |
| (IX) | 34908 | diisopropyl 2-[4-(acetoxy)-1,3-dithiolan-2-ylidene]malonate | C14H20O6S2 | 详情 | 详情 | |
| (X) | 34909 | diisopropyl 2-(4-hydroxy-1,3-dithiolan-2-ylidene)malonate | C12H18O5S2 | 详情 | 详情 |