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【结 构 式】

【分子编号】30688

【品名】4-chloro-3-([[(isopropylamino)carbonyl]amino]sulfonyl)pyridine

【CA登记号】

【 分 子 式 】C9H12ClN3O3S

【 分 子 量 】277.7314

【元素组成】C 38.92% H 4.36% Cl 12.77% N 15.13% O 17.28% S 11.55%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

2) By condensation of m-toluidine (III) with 1-isopropyl-3-(4-chloro-3-pyridylsulfonyl)urea (IV) by means of Cu at 95 C.

1 Delarge, J.E.; Lapiere, C.L.; Georges, A.M. (A. Christiaens SA); 3-Loweralkylcarbamylsulfonamido-4-phenylaminopyridine-N-oxides, derivatives thereof and pharmaceutical compositions containing same. BE 0827844; CH 609045; CH 610890; DD 121936; DD 126887; DE 2516025; FR 2267775; GB 1477664; JP 50142571; NL 7504521; US 4018929; US 4055650; ZA 7502243 .
2 Castaner, J.; Blancafort, P.; Thorpe, P.; Serradell, M.N.; Torasemide. Drugs Fut 1983, 8, 3, 223.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(III) 30687 3-methylphenylamine; m-toluidine 108-44-1 C7H9N 详情 详情
(IV) 30688 4-chloro-3-([[(isopropylamino)carbonyl]amino]sulfonyl)pyridine C9H12ClN3O3S 详情 详情
Extended Information