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【结 构 式】 
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【药物名称】Torsemide, Torasemide, BM-02015, JDL-464, AC-4464, GJ-1090, Sutril, Torocard, Torasemide N, Unat, Dilutol, Luprac, Torem, Torrem, Toradiur, Demadex, Sutril 【化学名称】1-Isopropyl-3-[4-(3-methylphenylamino)pyridin-3-ylsulfonyl]urea 【CA登记号】56211-40-6 【 分 子 式 】C16H20N4O3S 【 分 子 量 】348.4268 |
【开发单位】Nycomed Pharma (Originator), Ferrer (Licensee), Malesci (Licensee), Roche (Licensee), Toyama (Licensee), Pliva (Generic) 【药理作用】CARDIOVASCULAR DRUGS, Diuretics, Hypertension, Treatment of, Loop Diuretics, RENAL-UROLOGIC DRUGS |
合成路线1
1) By condensation of 3-sulfonamido-4-(3-methylanilino)pyridine (I) with isopropylisocyanate (II) by means of triethylamine at 95 C.
| 【1】 Delarge, J.E.; Lapiere, C.L.; Georges, A.M. (A. Christiaens SA); 3-Loweralkylcarbamylsulfonamido-4-phenylaminopyridine-N-oxides, derivatives thereof and pharmaceutical compositions containing same. BE 0827844; CH 609045; CH 610890; DD 121936; DD 126887; DE 2516025; FR 2267775; GB 1477664; JP 50142571; NL 7504521; US 4018929; US 4055650; ZA 7502243 . |
| 【2】 Castaner, J.; Blancafort, P.; Thorpe, P.; Serradell, M.N.; Torasemide. Drugs Fut 1983, 8, 3, 223. |
合成路线2
2) By condensation of m-toluidine (III) with 1-isopropyl-3-(4-chloro-3-pyridylsulfonyl)urea (IV) by means of Cu at 95 C.
| 【1】 Delarge, J.E.; Lapiere, C.L.; Georges, A.M. (A. Christiaens SA); 3-Loweralkylcarbamylsulfonamido-4-phenylaminopyridine-N-oxides, derivatives thereof and pharmaceutical compositions containing same. BE 0827844; CH 609045; CH 610890; DD 121936; DD 126887; DE 2516025; FR 2267775; GB 1477664; JP 50142571; NL 7504521; US 4018929; US 4055650; ZA 7502243 . |
| 【2】 Castaner, J.; Blancafort, P.; Thorpe, P.; Serradell, M.N.; Torasemide. Drugs Fut 1983, 8, 3, 223. |