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【结 构 式】 
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【分子编号】30653 【品名】2,4-dichloro-6-(2,5-dichlorophenyl)-1,3,5-triazine 【CA登记号】 |
【 分 子 式 】C9H3Cl4N3 【 分 子 量 】294.95384 【元素组成】C 36.65% H 1.03% Cl 48.08% N 14.25% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)This compound can be obtained by two different ways: 1) By cyclization of 2,5-dichlorobenzonitrile (I) with dicyandiamide (II) with KOH in refluxing methyl cellosolve, followed by treatment with maleic acid in dioxane. 2) By treatment of 2,4-dichloro-6-(2,5-dichlorophenyl)-s-triazine (III) with 28% aqueous ammonia at 100 C.
| 【1】 Murai, H.; Ohata, K.; Aoyagi, Y.; Ueda, F.; Kitano, M.; Takata, S.; Toda, S. (Nippon Shinyaku Co., Ltd.); Benzoguanamine derivatives. CH 592638; DE 2506814; FR 2261009; GB 1441904; JP 77111086; JP 7746955; NL 7501575; US 3966728 . |
| 【2】 Murai, H.; Ohata, K.; Aoyagi, Y.; Ueda, F. (Nippon Shinyaku Co., Ltd.); Dihalobenzoguanamines with anti-ulcus activity. CH 596193; JP 51075083; NL 7514062 . |
| 【3】 Serradell, M.N.; Blancafort, P.; Castaner, J.; MN-1695. Drugs Fut 1983, 8, 6, 502. |
Extended Information