【结 构 式】 |
【分子编号】30652 【品名】2,5-dichlorobenzonitrile 【CA登记号】21663-61-6 |
【 分 子 式 】C7H3Cl2N 【 分 子 量 】172.01296 【元素组成】C 48.88% H 1.76% Cl 41.22% N 8.14% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)This compound can be obtained by two different ways: 1) By cyclization of 2,5-dichlorobenzonitrile (I) with dicyandiamide (II) with KOH in refluxing methyl cellosolve, followed by treatment with maleic acid in dioxane. 2) By treatment of 2,4-dichloro-6-(2,5-dichlorophenyl)-s-triazine (III) with 28% aqueous ammonia at 100 C.
【1】 Murai, H.; Ohata, K.; Aoyagi, Y.; Ueda, F.; Kitano, M.; Takata, S.; Toda, S. (Nippon Shinyaku Co., Ltd.); Benzoguanamine derivatives. CH 592638; DE 2506814; FR 2261009; GB 1441904; JP 77111086; JP 7746955; NL 7501575; US 3966728 . |
【2】 Murai, H.; Ohata, K.; Aoyagi, Y.; Ueda, F. (Nippon Shinyaku Co., Ltd.); Dihalobenzoguanamines with anti-ulcus activity. CH 596193; JP 51075083; NL 7514062 . |
【3】 Serradell, M.N.; Blancafort, P.; Castaner, J.; MN-1695. Drugs Fut 1983, 8, 6, 502. |
Extended Information