1,4-dihydro-1-(2-fluoroethyl)-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylic acid; 6,7,8-trifluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid -Drug Synthesis Database

【结构式】

【分子编号】30589

【品名】1,4-dihydro-1-(2-fluoroethyl)-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylic acid; 6,7,8-trifluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

【CA登记号】

【分子式】C₁₂H₇F₄NO₃

【分子量】289.1861328

【元素组成】C 49.84% H 2.44% F 26.28% N 4.84% O 16.6%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (I) with 1-bromo-2-fluoroethane (II) by means of NaI in hot DMF gives 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (III), which is then condensed with N-methylpiperazine (IV) in refluxing pyridine.

参考文献中间体

合成目标

【1】 Irikura, T.; Koga, H.; Murayama, S. (Kyorin Pharmaceutical Co., Ltd.); Quinoline carboxylic acid derivatives and process for the preparation. BE 0887574; DE 3106013; FR 2499990; FR 2507183; US 4398029 .
【2】 Serradell, M.N.; Castaner, J.; AM-833. Drugs Fut 1984, 9, 4, 246.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30588	6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid		C₁₀H₄F₃NO₃	详情	详情
(II)	28769	1-bromo-2-fluoroethane	762-49-2	C₂H₄BrF	详情	详情
(III)	30589	1,4-dihydro-1-(2-fluoroethyl)-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylic acid; 6,7,8-trifluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid		C₁₂H₇F₄NO₃	详情	详情
(IV)	10061	1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine	109-01-3	C₅H₁₂N₂	详情	详情

Extended Information