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【结 构 式】 
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【分子编号】30588 【品名】6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 【CA登记号】 |
【 分 子 式 】C10H4F3NO3 【 分 子 量 】243.1419096 【元素组成】C 49.4% H 1.66% F 23.44% N 5.76% O 19.74% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The reaction of 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (I) with 1-bromo-2-fluoroethane (II) by means of NaI in hot DMF gives 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (III), which is then condensed with N-methylpiperazine (IV) in refluxing pyridine.
| 【1】 Irikura, T.; Koga, H.; Murayama, S. (Kyorin Pharmaceutical Co., Ltd.); Quinoline carboxylic acid derivatives and process for the preparation. BE 0887574; DE 3106013; FR 2499990; FR 2507183; US 4398029 . |
| 【2】 Serradell, M.N.; Castaner, J.; AM-833. Drugs Fut 1984, 9, 4, 246. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 30588 | 6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C10H4F3NO3 | 详情 | 详情 | |
| (II) | 28769 | 1-bromo-2-fluoroethane | 762-49-2 | C2H4BrF | 详情 | 详情 |
| (III) | 30589 | 1,4-dihydro-1-(2-fluoroethyl)-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylic acid; 6,7,8-trifluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C12H7F4NO3 | 详情 | 详情 | |
| (IV) | 10061 | 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine | 109-01-3 | C5H12N2 | 详情 | 详情 |
Extended Information