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【结 构 式】

【分子编号】30442

【品名】2-[1-(4-chlorobenzyl)-1H-indol-3-yl]-2-oxoacetyl chloride

【CA登记号】

【 分 子 式 】C17H11Cl2NO2

【 分 子 量 】332.18528

【元素组成】C 61.47% H 3.34% Cl 21.35% N 4.22% O 9.63%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The condensation of 1H-indole (I) with 4-chlorobenzyl chloride (II) by means of NaH in DMSO gives 1-(4-chlorobenzyl) indole (III), which is treated with oxalyl chloride in a hot aprotic solvent yielding the intermediate acid chloride (IV). Finally, this compound is treated with pyridin-4-amine (V) in the same solvent.

1 Lebaut, G.; Menciu, C.; Kutscher, B.; Emig, P.; Szelenyi, S.; Brune, K. (Asta Medica AG); N-Substd. indol-3-glyoxylamide with antiasthmatic, antiallergic and immunosuppressive/immunomodulating effect. DE 19636150; EP 0931063; JP 2000505098; US 6008231; WO 9809946 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 15292 Indole; 1H-indole 120-72-9 C8H7N 详情 详情
(II) 10356 1-Chloro-4-(chloromethyl)benzene; 4-Chlorobenzyl chloride 104-83-6 C7H6Cl2 详情 详情
(III) 30441 1-(4-chlorobenzyl)-1H-indole C15H12ClN 详情 详情
(IV) 30442 2-[1-(4-chlorobenzyl)-1H-indol-3-yl]-2-oxoacetyl chloride C17H11Cl2NO2 详情 详情
(V) 25661 4-pyridinamine; 4-aminopyridine 5044-74-5 C5H6N2 详情 详情
Extended Information