1-(4-chlorobenzyl)-1H-indole -Drug Synthesis Database

【结构式】

【分子编号】30441

【品名】1-(4-chlorobenzyl)-1H-indole

【CA登记号】

【分子式】C₁₅H₁₂ClN

【分子量】241.71972

【元素组成】C 74.53% H 5% Cl 14.67% N 5.79%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of 1H-indole (I) with 4-chlorobenzyl chloride (II) by means of NaH in DMSO gives 1-(4-chlorobenzyl) indole (III), which is treated with oxalyl chloride in a hot aprotic solvent yielding the intermediate acid chloride (IV). Finally, this compound is treated with pyridin-4-amine (V) in the same solvent.

参考文献中间体

合成目标

【1】 Lebaut, G.; Menciu, C.; Kutscher, B.; Emig, P.; Szelenyi, S.; Brune, K. (Asta Medica AG); N-Substd. indol-3-glyoxylamide with antiasthmatic, antiallergic and immunosuppressive/immunomodulating effect. DE 19636150; EP 0931063; JP 2000505098; US 6008231; WO 9809946 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	15292	Indole; 1H-indole	120-72-9	C₈H₇N	详情	详情
(II)	10356	1-Chloro-4-(chloromethyl)benzene; 4-Chlorobenzyl chloride	104-83-6	C₇H₆Cl₂	详情	详情
(III)	30441	1-(4-chlorobenzyl)-1H-indole		C₁₅H₁₂ClN	详情	详情
(IV)	30442	2-[1-(4-chlorobenzyl)-1H-indol-3-yl]-2-oxoacetyl chloride		C₁₇H₁₁Cl₂NO₂	详情	详情
(V)	25661	4-pyridinamine; 4-aminopyridine	5044-74-5	C₅H₆N₂	详情	详情

Extended Information