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【结 构 式】 
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【分子编号】35437 【品名】4-hydroxyphenyl acetate 【CA登记号】 |
【 分 子 式 】C8H8O3 【 分 子 量 】152.14972 【元素组成】C 63.15% H 5.3% O 31.55% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)Compound (XII) is selectively debenzoylated with sodium methoxide in methanol yielding the monobenzoyl ester (XIII). The acylation of (XIII) with phosgene, triethylamine and monoacetyl hydroquinone (XIV) affords the carbonate ester (XV), which is selectively demethylated with MgI2 and deacetylated with NaHCO3 to afford the target Calpostin C.
| 【1】 Merlic, C.A.; et al.; Total synthesis of the calphostins: Application of fischer carbene complexes and thermodynamic control of atropisomers. J Org Chem 2001, 66, 4, 1297. |
| 【2】 Merlic, C.A.; et al.; Carbene complexes in the synthesis of complex natural products: Total synthesis of the calphostins. J Am Chem Soc 2000, 122, 13, 3224. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XII) | 35435 | (1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-2,4,6,7,9,11-hexamethoxy-3,10-dioxo-3,10-dihydro-1-perylenyl]-1-methylethyl benzoate | C46H42O12 | 详情 | 详情 | |
| (XIII) | 35436 | (1R)-2-[12-[(2R)-2-hydroxypropyl]-2,4,6,7,9,11-hexamethoxy-3,10-dioxo-3,10-dihydro-1-perylenyl]-1-methylethyl benzoate | C39H38O11 | 详情 | 详情 | |
| (XIV) | 35437 | 4-hydroxyphenyl acetate | C8H8O3 | 详情 | 详情 | |
| (XV) | 35438 | (1R)-2-[12-[(2R)-2-([[4-(acetoxy)phenoxy]carbonyl]oxy)propyl]-2,4,6,7,9,11-hexamethoxy-3,10-dioxo-3,10-dihydro-1-perylenyl]-1-methylethyl benzoate | C48H44O15 | 详情 | 详情 |
Extended Information