1,2,4-tris(2-oxiranylmethyl)-1,2,4-triazolidine-3,5-dione -Drug Synthesis Database

【结构式】

【分子编号】30372

【品名】1,2,4-tris(2-oxiranylmethyl)-1,2,4-triazolidine-3,5-dione

【CA登记号】

【分子式】C₁₁H₁₅N₃O₅

【分子量】269.25732

【元素组成】C 49.07% H 5.62% N 15.61% O 29.71%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

For synthesizing alpha/beta-TGU a mixture of urazole (I), epichlorohydrin (II) and tetramethylammonium bromide or benzalcon A was heated to yield the corresponding chlorohydrin intermediate (III), which was converted to alpha/beta-TGU by addition of sodium hydroxide and purified by column chromatography or recrystallization.

参考文献中间体

合成目标

【1】 Fischer, H.; et al. (Henkel KgA); N-Substituted polyglycidyl urazole compounds, processes for their production and pharmaceutical preparations. EP 0056962; JP 57142982; US 4801601 .
【2】 Castaner, J.; Serradell, M.N.; Triglycidylurazol. Drugs Fut 1984, 9, 3, 209.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30371	1,2,4-triazolidine-3,5-dione	3232-84-6	C₂H₃N₃O₂	详情	详情
(II)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(III)	30372	1,2,4-tris(2-oxiranylmethyl)-1,2,4-triazolidine-3,5-dione		C₁₁H₁₅N₃O₅	详情	详情

Extended Information