【结 构 式】 |
【分子编号】30371 【品名】1,2,4-triazolidine-3,5-dione 【CA登记号】3232-84-6 |
【 分 子 式 】C2H3N3O2 【 分 子 量 】101.06484 【元素组成】C 23.77% H 2.99% N 41.58% O 31.66% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)For synthesizing alpha/beta-TGU a mixture of urazole (I), epichlorohydrin (II) and tetramethylammonium bromide or benzalcon A was heated to yield the corresponding chlorohydrin intermediate (III), which was converted to alpha/beta-TGU by addition of sodium hydroxide and purified by column chromatography or recrystallization.
【1】 Fischer, H.; et al. (Henkel KgA); N-Substituted polyglycidyl urazole compounds, processes for their production and pharmaceutical preparations. EP 0056962; JP 57142982; US 4801601 . |
【2】 Castaner, J.; Serradell, M.N.; Triglycidylurazol. Drugs Fut 1984, 9, 3, 209. |
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