【结 构 式】 |
【分子编号】30205 【品名】(E)-1-(2,3-dichlorophenyl)-2-(2-pyridinyl)-1-ethenol 【CA登记号】 |
【 分 子 式 】C13H9Cl2NO 【 分 子 量 】266.126 【元素组成】C 58.67% H 3.41% Cl 26.64% N 5.26% O 6.01% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The condensation of 2-methylpyridine (I) with 2,3-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.
【1】 Mettey, Y.; Vierfond, J.-M.; Benzo[c]quinoliziums: A new family of inhibitors for protein kinase CK II. Bioorg Med Chem Lett 1997, 7, 8, 961. |
【2】 Becq, F.; Mettey, Y.; Vierfond, J.-M.; Verrier, B.; Gola, M. (CNRS (Centre National de la Recherche Scientifique)); CFTR channel activator cpds. and pharmaceutical compsns. containing same. EP 0937044; WO 9805642 . |
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