MPB-07, -Drug Synthesis Database

【结构式】

【药物名称】MPB-07

【化学名称】10-Chloro-6-hydroxybenzo[c]quinolizinium chloride

【CA登记号】191091-55-1

【分子式】C₁₃H₉Cl₂NO

【分子量】266.12878

【开发单位】INSERM (Originator)

【药理作用】Correction of Mucus Abnormalities, Cystic Fibrosis, Treatment of , RESPIRATORY DRUGS, Casein Kinase II (CK2) Inhibitors, CFTR Channel Activators, Protein Kinase C (PKC) Inhibitors

合成路线1

The condensation of 2-methylpyridine (I) with 2,3-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.

参考文献中间体

【1】 Mettey, Y.; Vierfond, J.-M.; Benzo[c]quinoliziums: A new family of inhibitors for protein kinase CK II. Bioorg Med Chem Lett 1997, 7, 8, 961.
【2】 Becq, F.; Mettey, Y.; Vierfond, J.-M.; Verrier, B.; Gola, M. (CNRS (Centre National de la Recherche Scientifique)); CFTR channel activator cpds. and pharmaceutical compsns. containing same. EP 0937044; WO 9805642 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	17590	2-methylpyridine; 2-picoline	109-06-8	C₆H₇N	详情	详情
(II)	30204	2,3-dichlorobenzonitrile	6574-97-6	C₇H₃Cl₂N	详情	详情
(III)	30205	(E)-1-(2,3-dichlorophenyl)-2-(2-pyridinyl)-1-ethenol		C₁₃H₉Cl₂NO	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)