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【结 构 式】

【分子编号】29985

【品名】3-methyl-2-(3,4,5-trimethoxyphenyl)butanenitrile

【CA登记号】

【 分 子 式 】C14H19NO3

【 分 子 量 】249.3098

【元素组成】C 67.45% H 7.68% N 5.62% O 19.25%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

Gallopamil is obtained by condensing 2-(3,4,5-trimethoxypheny)-3-methylbutyronitrile (I) with N-(3-chloropropyl)-N-(2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (II) in the presence of bases. Compound (I) can be prepared by reaction of 3,4,5-trimethoxyphenylacetonitrile (III) with isopropyl chloride (IV) by means of NaNH2. Compound (II) is formed from 1-bromo-3-chloropropane (V) and N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (VI).

1 Dengel, F. (Knoll AG); Verfahren zur herstellung basisch substituerter phenylacetonitrile. DE 1154810; DE 1158083 .
2 Mannhold, R.; Gallopamil Hydrochloride. Drugs Fut 1984, 9, 2, 108.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 29985 3-methyl-2-(3,4,5-trimethoxyphenyl)butanenitrile C14H19NO3 详情 详情
(II) 29986 3-chloro-N-(3,4-dimethoxyphenethyl)-N-methyl-1-propanamine; N-(3-chloropropyl)-N-(3,4-dimethoxyphenethyl)-N-methylamine C14H22ClNO2 详情 详情
(III) 29983 2-(3,4,5-trimethoxyphenyl)acetonitrile 13338-63-1 C11H13NO3 详情 详情
(IV) 29984 2-chloropropane 75-29-6 C3H7Cl 详情 详情
(V) 10358 1-Bromo-3-chloropropane 109-70-6 C3H6BrCl 详情 详情
(VI) 18938 2-(3,4-dimethoxyphenyl)-N-methyl-1-ethanamine; N-(3,4-dimethoxyphenethyl)-N-methylamine 3490-06-0 C11H17NO2 详情 详情
Extended Information