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【结 构 式】 
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【药物名称】Gallopamil hydrochloride, D-600, Algocor, Procorum 【化学名称】5-[N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methylamino]-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile hydrochloride 【CA登记号】16662-47-8 (free base) 【 分 子 式 】C28H41ClN2O5 【 分 子 量 】521.10237 |
【开发单位】Abbott (Originator), Grünenthal (Originator), Ravizza (Licensee) 【药理作用】Angina pectoris, Treatment of, CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Calcium Channel Blockers |
合成路线1
Gallopamil is obtained by condensing 2-(3,4,5-trimethoxypheny)-3-methylbutyronitrile (I) with N-(3-chloropropyl)-N-(2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (II) in the presence of bases. Compound (I) can be prepared by reaction of 3,4,5-trimethoxyphenylacetonitrile (III) with isopropyl chloride (IV) by means of NaNH2. Compound (II) is formed from 1-bromo-3-chloropropane (V) and N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (VI).
| 【1】 Dengel, F. (Knoll AG); Verfahren zur herstellung basisch substituerter phenylacetonitrile. DE 1154810; DE 1158083 . |
| 【2】 Mannhold, R.; Gallopamil Hydrochloride. Drugs Fut 1984, 9, 2, 108. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29985 | 3-methyl-2-(3,4,5-trimethoxyphenyl)butanenitrile | C14H19NO3 | 详情 | 详情 | |
| (II) | 29986 | 3-chloro-N-(3,4-dimethoxyphenethyl)-N-methyl-1-propanamine; N-(3-chloropropyl)-N-(3,4-dimethoxyphenethyl)-N-methylamine | C14H22ClNO2 | 详情 | 详情 | |
| (III) | 29983 | 2-(3,4,5-trimethoxyphenyl)acetonitrile | 13338-63-1 | C11H13NO3 | 详情 | 详情 |
| (IV) | 29984 | 2-chloropropane | 75-29-6 | C3H7Cl | 详情 | 详情 |
| (V) | 10358 | 1-Bromo-3-chloropropane | 109-70-6 | C3H6BrCl | 详情 | 详情 |
| (VI) | 18938 | 2-(3,4-dimethoxyphenyl)-N-methyl-1-ethanamine; N-(3,4-dimethoxyphenethyl)-N-methylamine | 3490-06-0 | C11H17NO2 | 详情 | 详情 |