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【结 构 式】

【分子编号】29657

【品名】1-(1-[2-[(3-chlorobenzyl)oxy]phenyl]vinyl)-1H-imidazole; 3-chlorobenzyl 2-[1-(1H-imidazol-1-yl)vinyl]phenyl ether

【CA登记号】

【 分 子 式 】C18H15ClN2O

【 分 子 量 】310.78268

【元素组成】C 69.57% H 4.86% Cl 11.41% N 9.01% O 5.15%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

This 1-vinyl derivative (II) is obtained by reaction of N,N'-thionyldiimidazole (A) with o-hydroxyacetophenone (I) in dichloromethane at room temperature. Treatment of (II) with m-chlorobenzyl chloride (B) in the presence of KOH in DMF gives the m-chlorobenzyl ether (III). The hydrochloride can be prepared by treatment of (III) with HCl in AcOEt.

1 Ogata, M.; Hamada, Y.; Takehara, M.; Tawara, K.; Matsumoto, H.; 1-[1-[2-[(3-Chlorobenzyl)oxy]phenyl]vinyl]-1H-imidazole hydrochloride, a new potent antifungal agent. J Med Chem 1983, 26, 5, 768-770.
2 Ogata, M.; Tawara, K.; Cloconazole Hydrochloride. Drugs Fut 1985, 10, 6, 451.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 29654 2-hydroxyacetophenone; 1-(2-hydroxyphenyl)-1-ethanone 118-93-4 C8H8O2 详情 详情
(II) 26955 3-phenyl-1,1-cyclobutanedicarboxylic acid C12H12O4 详情 详情
(III) 26956 3-phenylcyclobutanecarboxylic acid C11H12O2 详情 详情
(IV) 20642 1-chloro-3-(chloromethyl)benzene; 3-Chlorobenzyl chloride 620-20-2 C7H6Cl2 详情 详情
(V) 29657 1-(1-[2-[(3-chlorobenzyl)oxy]phenyl]vinyl)-1H-imidazole; 3-chlorobenzyl 2-[1-(1H-imidazol-1-yl)vinyl]phenyl ether C18H15ClN2O 详情 详情
Extended Information