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【结 构 式】 
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【药物名称】Croconazole hydrochloride, Cloconazole hydrochloride, 710674S, Pilzcin 【化学名称】1-[1-[2-(3-Chlorophenyl)methoxy]phenyl]vinyl]-1H-imidazole monohydrochloride 【CA登记号】77174-66-4, 77175-51-0 (free base) 【 分 子 式 】C18H16Cl2N2O 【 分 子 量 】347.24702 |
【开发单位】Shionogi (Originator), Merz (Licensee) 【药理作用】Antifungal Agents, ANTIINFECTIVE THERAPY |
合成路线1
This 1-vinyl derivative (II) is obtained by reaction of N,N'-thionyldiimidazole (A) with o-hydroxyacetophenone (I) in dichloromethane at room temperature. Treatment of (II) with m-chlorobenzyl chloride (B) in the presence of KOH in DMF gives the m-chlorobenzyl ether (III). The hydrochloride can be prepared by treatment of (III) with HCl in AcOEt.
| 【1】 Ogata, M.; Hamada, Y.; Takehara, M.; Tawara, K.; Matsumoto, H.; 1-[1-[2-[(3-Chlorobenzyl)oxy]phenyl]vinyl]-1H-imidazole hydrochloride, a new potent antifungal agent. J Med Chem 1983, 26, 5, 768-770. |
| 【2】 Ogata, M.; Tawara, K.; Cloconazole Hydrochloride. Drugs Fut 1985, 10, 6, 451. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29654 | 2-hydroxyacetophenone; 1-(2-hydroxyphenyl)-1-ethanone | 118-93-4 | C8H8O2 | 详情 | 详情 |
| (II) | 26955 | 3-phenyl-1,1-cyclobutanedicarboxylic acid | C12H12O4 | 详情 | 详情 | |
| (III) | 26956 | 3-phenylcyclobutanecarboxylic acid | C11H12O2 | 详情 | 详情 | |
| (IV) | 20642 | 1-chloro-3-(chloromethyl)benzene; 3-Chlorobenzyl chloride | 620-20-2 | C7H6Cl2 | 详情 | 详情 |
| (V) | 29657 | 1-(1-[2-[(3-chlorobenzyl)oxy]phenyl]vinyl)-1H-imidazole; 3-chlorobenzyl 2-[1-(1H-imidazol-1-yl)vinyl]phenyl ether | C18H15ClN2O | 详情 | 详情 |
Extended Information