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【结 构 式】 
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【分子编号】29621 【品名】[(2R,3S,4S,5R)-3,4-bis(benzoyloxy)-5-[2-oxo-4-thioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-thiophenyl]methyl benzoate 【CA登记号】 |
【 分 子 式 】C30H24N2O7S2 【 分 子 量 】588.66184 【元素组成】C 61.21% H 4.11% N 4.76% O 19.03% S 10.89% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)In a related procedure, arabinofuranosyl bromide (III) was condensed with bis(trimethylsilyl)uracil (VI) to afford, after chromatographic separation, the beta-nucleoside (VII). Subsequent treatment of (VII) with P2S5 produced the 4-thiouridine analogue (VIII). Then, treatment of this derivative with methanolic ammonia at 110 C in a sealed tube yielded the title arabinofuranosyl citosine.
| 【1】 Whistler, R.L.; et al.; 4-Thio-D-arabinofuranosylpyrimidine nucleosides. J Org Chem 1971, 36, 1, 108. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 29616 | [(2R,3S,4S,5S)-3,4-bis(benzoyloxy)-5-bromotetrahydro-2-thiophenyl]methyl benzoate | C26H21BrO6S | 详情 | 详情 | |
| (VI) | 29619 | 2,4-bis[(trimethylsilyl)oxy]pyrimidine; trimethylsilyl 2-[(trimethylsilyl)oxy]-4-pyrimidinyl ether | C10H20N2O2Si2 | 详情 | 详情 | |
| (VII) | 29620 | (2R,3S,4S,5R)-4-(benzoyloxy)-5-[(benzoyloxy)methyl]-2-[2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-3-thiophenyl benzoate | C30H24N2O8S | 详情 | 详情 | |
| (VIII) | 29621 | [(2R,3S,4S,5R)-3,4-bis(benzoyloxy)-5-[2-oxo-4-thioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-thiophenyl]methyl benzoate | C30H24N2O7S2 | 详情 | 详情 |
Extended Information