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【结 构 式】

【分子编号】29620

【品名】(2R,3S,4S,5R)-4-(benzoyloxy)-5-[(benzoyloxy)methyl]-2-[2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-3-thiophenyl benzoate

【CA登记号】

【 分 子 式 】C30H24N2O8S

【 分 子 量 】572.59524

【元素组成】C 62.93% H 4.22% N 4.89% O 22.35% S 5.6%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VII)

In a related procedure, arabinofuranosyl bromide (III) was condensed with bis(trimethylsilyl)uracil (VI) to afford, after chromatographic separation, the beta-nucleoside (VII). Subsequent treatment of (VII) with P2S5 produced the 4-thiouridine analogue (VIII). Then, treatment of this derivative with methanolic ammonia at 110 C in a sealed tube yielded the title arabinofuranosyl citosine.

1 Whistler, R.L.; et al.; 4-Thio-D-arabinofuranosylpyrimidine nucleosides. J Org Chem 1971, 36, 1, 108.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(III) 29616 [(2R,3S,4S,5S)-3,4-bis(benzoyloxy)-5-bromotetrahydro-2-thiophenyl]methyl benzoate C26H21BrO6S 详情 详情
(VI) 29619 2,4-bis[(trimethylsilyl)oxy]pyrimidine; trimethylsilyl 2-[(trimethylsilyl)oxy]-4-pyrimidinyl ether C10H20N2O2Si2 详情 详情
(VII) 29620 (2R,3S,4S,5R)-4-(benzoyloxy)-5-[(benzoyloxy)methyl]-2-[2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-3-thiophenyl benzoate C30H24N2O8S 详情 详情
(VIII) 29621 [(2R,3S,4S,5R)-3,4-bis(benzoyloxy)-5-[2-oxo-4-thioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-thiophenyl]methyl benzoate C30H24N2O7S2 详情 详情
Extended Information