• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】29613

【品名】phenyl 6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinylcarbamate

【CA登记号】

【 分 子 式 】C18H15N3O3

【 分 子 量 】321.33552

【元素组成】C 67.28% H 4.71% N 13.08% O 14.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XIV)

Coupling of 3-hydroxypyridine (X) with 2-chloropyridine (XI) afforded the corresponding dipyridyl ether (XII). After reduction of the nitro group of (XII) with SnCl2, the resulting aminopyridine (XIII) was treated with phenyl chloroformate to give the phenyl carbamate (XIV). Finally, condensation of carbamate (XIV) with indoline (IX) produced the title carboxamide.

1 Bromidge, S.M.; Forbes, I.T. (SmithKline Beecham plc); Indoline derivs. useful as 5-HT-2C receptor antagonists. EP 0912554; WO 9748699 .
2 Blackburn, T.P. (SmithKline Beecham plc); Pharmaceutical compsn. containing a 5HT2C antagonist and a D2 antagonist. WO 9804289 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IX) 29608 5-methyl-6-(trifluoromethyl)indoline C10H10F3N 详情 详情
(X) 29609 2-methyl-3-pyridinol 1121-25-1 C6H7NO 详情 详情
(XI) 29610 2-chloro-5-nitropyridine 4548-45-2 C5H3ClN2O2 详情 详情
(XII) 29611 2-methyl-3-[(5-nitro-2-pyridinyl)oxy]pyridine; 2-methyl-3-pyridinyl 5-nitro-2-pyridinyl ether C11H9N3O3 详情 详情
(XIII) 29612 6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinamine; 6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinylamine C11H11N3O 详情 详情
(XIV) 29613 phenyl 6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinylcarbamate C18H15N3O3 详情 详情
Extended Information