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【结 构 式】 
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【分子编号】29611 【品名】2-methyl-3-[(5-nitro-2-pyridinyl)oxy]pyridine; 2-methyl-3-pyridinyl 5-nitro-2-pyridinyl ether 【CA登记号】 |
【 分 子 式 】C11H9N3O3 【 分 子 量 】231.21088 【元素组成】C 57.14% H 3.92% N 18.17% O 20.76% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XII)Coupling of 3-hydroxypyridine (X) with 2-chloropyridine (XI) afforded the corresponding dipyridyl ether (XII). After reduction of the nitro group of (XII) with SnCl2, the resulting aminopyridine (XIII) was treated with phenyl chloroformate to give the phenyl carbamate (XIV). Finally, condensation of carbamate (XIV) with indoline (IX) produced the title carboxamide.
| 【1】 Bromidge, S.M.; Forbes, I.T. (SmithKline Beecham plc); Indoline derivs. useful as 5-HT-2C receptor antagonists. EP 0912554; WO 9748699 . |
| 【2】 Blackburn, T.P. (SmithKline Beecham plc); Pharmaceutical compsn. containing a 5HT2C antagonist and a D2 antagonist. WO 9804289 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 29608 | 5-methyl-6-(trifluoromethyl)indoline | C10H10F3N | 详情 | 详情 | |
| (X) | 29609 | 2-methyl-3-pyridinol | 1121-25-1 | C6H7NO | 详情 | 详情 |
| (XI) | 29610 | 2-chloro-5-nitropyridine | 4548-45-2 | C5H3ClN2O2 | 详情 | 详情 |
| (XII) | 29611 | 2-methyl-3-[(5-nitro-2-pyridinyl)oxy]pyridine; 2-methyl-3-pyridinyl 5-nitro-2-pyridinyl ether | C11H9N3O3 | 详情 | 详情 | |
| (XIII) | 29612 | 6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinamine; 6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinylamine | C11H11N3O | 详情 | 详情 | |
| (XIV) | 29613 | phenyl 6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinylcarbamate | C18H15N3O3 | 详情 | 详情 |
Extended Information