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【结 构 式】 
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【分子编号】29404 【品名】1H-1,2,3-triazole 【CA登记号】288-36-8 |
【 分 子 式 】C2H3N3 【 分 子 量 】69.06604 【元素组成】C 34.78% H 4.38% N 60.84% |
合成路线1
该中间体在本合成路线中的序号：(I)The reaction between 1,2,3-triazole (I) and 3,4-difluoronitrobenzene (II) afforded a mixture of two regioisomeric substituted triazoles (III) and (IV), from which the required 1-substituted isomer (III) was isolated by column chromatography. Reduction of the nitro group of (III) by hydrogenation over Raney-Ni gave aniline (V), which was converted to carbamate (VI) upon treatment with benzyl chloroformate. Subsequent condensation of (VI) with (R)-(-)-glycidyl butyrate (VII) in the presence of lithium bis(trimethylsilyl)amide produced the chiral oxazolidinone (VIII). Mesylation of the alcohol group of (VIII), followed by displacement with NaN3 yielded azide (IX). This was reduced by hydrogenation over Raney-Ni to give amine (X), which was finally acetylated using Ac2O and pyridine.
| 【1】 Emmert, D.E.; Reischer, R.J.; Ford, C.W.; Garmon, S.A.; Zurenko, G.E.; Barbachyn, M.R.; Hutchinson, D.K.; Stelzer, L.S.; Hester, J.B.; Synthesis and antibacterial activity of azolylphenyloxazolidinones having nitrogen-bound five-membered heterocyclic rings. 38th Intersci Conf Antimicrob Agents Chemother (Sept 24 1998, San Diego) 1998, Abst F-137. |
| 【2】 Hutchinson, D.K. (Pharmacia & Upjohn AB); Hetero-aromatic ring substd. phenyloxazolidinone antimicrobials. EP 0807112; JP 1998513446; US 5910504; WO 9623788 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10101 | Benzyloxycarbonyl chloride; Benzyl chloroformate; 1-[[(Chlorocarbonyl)oxy]methyl]benzene | 501-53-1 | C8H7ClO2 | 详情 | 详情 | |
| (I) | 29404 | 1H-1,2,3-triazole | 288-36-8 | C2H3N3 | 详情 | 详情 |
| (II) | 17013 | 1,2-difluoro-4-nitrobenzene; 3,4-Difluoronitrobenzene | 369-34-6 | C6H3F2NO2 | 详情 | 详情 |
| (III) | 29405 | 1-(2-fluoro-4-nitrophenyl)-1H-1,2,3-triazole | C8H5FN4O2 | 详情 | 详情 | |
| (IV) | 29406 | 2-(2-fluoro-4-nitrophenyl)-2H-1,2,3-triazole | C8H5FN4O2 | 详情 | 详情 | |
| (V) | 29407 | 3-fluoro-4-(1H-1,2,3-triazol-1-yl)phenylamine3-fluoro-4-(1H-1,2,3-triazol-1-yl)aniline | C8H7FN4 | 详情 | 详情 | |
| (VI) | 29408 | benzyl 3-fluoro-4-(1H-1,2,3-triazol-1-yl)phenylcarbamate | C16H13FN4O2 | 详情 | 详情 | |
| (VII) | 18385 | (2R)oxiranylmethyl butyrate;(R)-glycidyl butyrate | 60456-26-0 | C7H12O3 | 详情 | 详情 |
| (VIII) | 29409 | (5R)-3-[3-fluoro-4-(1H-1,2,3-triazol-1-yl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one | C12H11FN4O3 | 详情 | 详情 | |
| (IX) | 29410 | (5R)-5-(azidomethyl)-3-[3-fluoro-4-(1H-1,2,3-triazol-1-yl)phenyl]-1,3-oxazolidin-2-one | C12H10FN7O2 | 详情 | 详情 | |
| (X) | 29411 | (5S)-5-(aminomethyl)-3-[3-fluoro-4-(1H-1,2,3-triazol-1-yl)phenyl]-1,3-oxazolidin-2-one | C12H12FN5O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(IV)The Vilsmeier-Haack reaction of 3-beta-acetoxyandrost-5-en-17-one (I) using POCl3 and DMF produced a mixture of the vinyl chloride (II) and its formyl derivative (III). After chromatographic separation, the chlorine atom of (III) was displaced with 1,2,3-triazole (IV) to afford the desired 1-triazolyl compound (V) along with the 2-triazolyl regioisomer (VI), which were separated by flash chromatography. Cleavage of the formyl group from compound (V) was carried out by treatment with bis(triphenylphosphine)rhodium(I)carbonyl chloride and 1,3-bis(diphenylphosphino)propane in hot xylenes to furnish (VII). The acetate ester group was finally hydrolyzed with methanolic KOH.
| 【1】 Njar, V.C.O.; Grigoryev, D.N.; Long, B.J.; Kato, K.; Brodie, A.M.H.; Nnane, I.P.; Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17alpha-hydroxylase-C17,20-lyase (P45017alpha): Potential agents for the treatment of prostate cancer. J Med Chem 1998, 41, 6, 902. |
| 【2】 Brodie, A.; Njar, V.C.O. (University of Maryland); 17-Azolyl steroids useful as androgen synthesis inhibitors. US 5994335 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 20083 | Prasterone acetate;3b-Hydroxy-5-androstene-17-one acetate；Dehydroisoandrosterone acetate;Dehydroepiandrosterone 3-acetate;Dehydroepiandrosterone acetate;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | 853-23-6 | C21H30O3 | 详情 | 详情 |
| (II) | 42853 | (3S,8R,9S,10R,13S,14S)-17-chloro-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C21H29ClO2 | 详情 | 详情 | |
| (III) | 42854 | (3S,8R,9S,10R,13S,14S)-17-chloro-16-formyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C22H29ClO3 | 详情 | 详情 | |
| (IV) | 29404 | 1H-1,2,3-triazole | 288-36-8 | C2H3N3 | 详情 | 详情 |
| (V) | 42856 | (3S,8R,9S,10R,13S,14S)-16-formyl-10,13-dimethyl-17-(2H-1,2,3-triazol-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C24H31N3O3 | 详情 | 详情 | |
| (VI) | 42855 | (3S,8R,9S,10R,13S,14S)-16-formyl-10,13-dimethyl-17-(1H-1,2,3-triazol-1-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C24H31N3O3 | 详情 | 详情 | |
| (VII) | 42857 | (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(1H-1,2,3-triazol-1-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C23H31N3O2 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(IV)The Vilsmeier-Haack formylation of 3-beta-acetoxyandrost-5-en-17-one (I) with POCl3/DMF provides the desired chloro aldehyde (III) along with minor amounts of the vinyl chloride (II), which are separated by column chromatography. Condensation of (III) with 1,2,3-triazole (IV) affords two regioisomeric triazole derivatives, (V) and (VI). After chromatographic isolation of the required 1-triazolyl compound (VI), decarbonylation of the 16-formyl group employing a modified Wilkinson’s catalyst gives (VII). The hydrolysis of the acetate group of (VII) with KOH in methanol gives the corresponding alcohol (VIII) , which is finally oxidized with aluminum isopropoxide and 1-methyl-4-piperidone in refluxing xylene.
| 【1】 Njar, V.C.O.; Grigoryev, D.N.; Long, B.J.; Kato, K.; Brodie, A.M.H.; Nnane, I.P.; Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17alpha-hydroxylase-C17,20-lyase (P45017alpha): Potential agents for the treatment of prostate cancer. J Med Chem 1998, 41, 6, 902. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 20083 | Prasterone acetate;3b-Hydroxy-5-androstene-17-one acetate；Dehydroisoandrosterone acetate;Dehydroepiandrosterone 3-acetate;Dehydroepiandrosterone acetate;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | 853-23-6 | C21H30O3 | 详情 | 详情 |
| (II) | 42853 | (3S,8R,9S,10R,13S,14S)-17-chloro-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C21H29ClO2 | 详情 | 详情 | |
| (III) | 42854 | (3S,8R,9S,10R,13S,14S)-17-chloro-16-formyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C22H29ClO3 | 详情 | 详情 | |
| (IV) | 29404 | 1H-1,2,3-triazole | 288-36-8 | C2H3N3 | 详情 | 详情 |
| (V) | 42856 | (3S,8R,9S,10R,13S,14S)-16-formyl-10,13-dimethyl-17-(2H-1,2,3-triazol-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C24H31N3O3 | 详情 | 详情 | |
| (VI) | 42855 | (3S,8R,9S,10R,13S,14S)-16-formyl-10,13-dimethyl-17-(1H-1,2,3-triazol-1-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C24H31N3O3 | 详情 | 详情 | |
| (VII) | 42857 | (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(1H-1,2,3-triazol-1-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C23H31N3O2 | 详情 | 详情 | |
| (VIII) | 42858 | (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(1H-1,2,3-triazol-1-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | C21H29N3O | 详情 | 详情 |