(E)-3-(3-pyridinyl)-2-propenoic acid -Drug Synthesis Database

【结构式】

【分子编号】29291

【品名】(E)-3-(3-pyridinyl)-2-propenoic acid

【CA登记号】19337-97-4

【分子式】C₈H₇NO₂

【分子量】149.14912

【元素组成】C 64.42% H 4.73% N 9.39% O 21.45%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Treatment of 3-(3-pyridyl)acrylic acid (I) with oxalyl chloride afforded the corresponding acid chloride (II). This was coupled with 1-trimethylsilyl-2-pyrrolidinone (IV) (prepared from pyrrolidinone (III) and hexamethyldisilazane), to produce the target imide.

参考文献中间体

合成目标

【1】 Nagasaka, T.; et al.; Synthesis of 1-trans-cinnamoyl- and 1-[trans-3-(pyridyl)acryloyl]-2-pyrrolidinone derivatives and their effect on hemicholinium-induced impairment of water maze learning in mice. Yakugaku Zasshi 1992, 112, 2, 100.
【2】 Nagasaka, T.; Yamada, H.; Hamaguchi, F. (Nisshin Flour Milling Co., Ltd.); Pyrrolidinone derivs.. JP 1990225458 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29291	(E)-3-(3-pyridinyl)-2-propenoic acid	19337-97-4	C₈H₇NO₂	详情	详情
(II)	29292	(E)-3-(3-pyridinyl)-2-propenoyl chloride		C₈H₆ClNO	详情	详情
(III)	27397	2-Pyrrolidinone	616-45-5	C₄H₇NO	详情	详情
(IV)	29293	1-(trimethylsilyl)-2-pyrrolidinone	14468-90-7	C₇H₁₅NOSi	详情	详情

Extended Information