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【结 构 式】 
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【药物名称】N-2733 【化学名称】1-[3-(3-Pyridinyl)-2(E)-propenoyl]-2-pyrrolidinone hydrochloride 【CA登记号】141236-60-4 (free base), 132220-88-3 (undefined isomer;free base) 【 分 子 式 】C12H13ClN2O2 【 分 子 量 】252.70261 |
【开发单位】Nisshin Pharma (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Treatment of Septic Shock, Antiinflammatory Drugs, TNF-alpha Production Inhibitors |
合成路线1
Treatment of 3-(3-pyridyl)acrylic acid (I) with oxalyl chloride afforded the corresponding acid chloride (II). This was coupled with 1-trimethylsilyl-2-pyrrolidinone (IV) (prepared from pyrrolidinone (III) and hexamethyldisilazane), to produce the target imide.
| 【1】 Nagasaka, T.; et al.; Synthesis of 1-trans-cinnamoyl- and 1-[trans-3-(pyridyl)acryloyl]-2-pyrrolidinone derivatives and their effect on hemicholinium-induced impairment of water maze learning in mice. Yakugaku Zasshi 1992, 112, 2, 100. |
| 【2】 Nagasaka, T.; Yamada, H.; Hamaguchi, F. (Nisshin Flour Milling Co., Ltd.); Pyrrolidinone derivs.. JP 1990225458 . |
Extended Information