|
【结 构 式】 
|
【分子编号】29273 【品名】N-(1H-indol-2-yl)-N-[2-[(E)-2-(1H-indol-3-yl)ethenyl]phenyl]amine 【CA登记号】 |
【 分 子 式 】C24H19N3 【 分 子 量 】349.43508 【元素组成】C 82.49% H 5.48% N 12.03% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(III)Treatment of an excess of indole (I) with dichloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III), which was cyclized and acylated to yield the title indolyl quinoline.
| 【1】 Chakrabarti, G.; et al.; Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis. J Antimicrob Chemother 1999, 43, 3, 359. |
| 【2】 Mahato, S.B.; et al.; Synthesis of indolylquinolines under Friedel-Crafts reaction conditions. Tetrahedron 1994, 50, 36, 10803. |
合成路线2
该中间体在本合成路线中的序号：(III)Treatment of an excess of indole (I) with chloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III), which was cyclized and acylated to yield the title indolyl quinoline.
| 【1】 Chakrabarti, G.; et al.; Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis. J Antimicrob Chemother 1999, 43, 3, 359. |
| 【2】 Mahato, S.B.; et al.; Synthesis of indolylquinolines under Friedel-Crafts reaction conditions. Tetrahedron 1994, 50, 36, 10803. |
Extended Information