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【结 构 式】 
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【药物名称】 【化学名称】2-Chloro-N-[2-[3-(1H-indol-3-yl)-2-quinolinylmethyl]phenyl]acetamide 【CA登记号】159018-54-9 【 分 子 式 】C26H20ClN3O 【 分 子 量 】425.9218 |
【开发单位】Indian Institute of Chemical Biology (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antileishmanials, Treatment of Protozoal Diseases |
合成路线1
Treatment of an excess of indole (I) with chloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III), which was cyclized and acylated to yield the title indolyl quinoline.
| 【1】 Chakrabarti, G.; et al.; Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis. J Antimicrob Chemother 1999, 43, 3, 359. |
| 【2】 Mahato, S.B.; et al.; Synthesis of indolylquinolines under Friedel-Crafts reaction conditions. Tetrahedron 1994, 50, 36, 10803. |
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