|
【结 构 式】 
|
【分子编号】29240 【品名】1,4-dioxepan-5-yl isopropyl ether 【CA登记号】 |
【 分 子 式 】C8H16O3 【 分 子 量 】160.21324 【元素组成】C 59.98% H 10.07% O 29.96% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)By reaction of 5-isopropoxy-1,4-dioxepane (I) with 5-fluorouracil (II) by means of SnCl4, hexamethyldisilazane (HMDS) and trimethylchlorosilane (TCS) in acetonitrile.
| 【1】 Gallo, M.A.; et al.; A facile synthetic method for pyrimidine acyclonucleoside analogues from alkoxy-1,4-diheterocycloheptanes. Synlett 1993, 6, 389. |
| 【2】 Campos, J.; et al.; Diheterocyclanes as synthons for the preparation of novel series of nucleoside and acyclonucleoside analogues. Farmaco 1997, 52, 5, 263. |
| 【3】 Campos Rosa, J.; Gallo Mezo, M.A.; Dominguez Senglar, J.F.; Entrena Guadix, A.; Pineda de las Infantas y Villatoro, M.J.; Camacho Quesada, E.; Espinosa Ubeda, A. (Universidad de Granada); New uracil derivs. having an anti-tumour activity and related cpds. (N-1 derivs. of 5-substd.-uracile). WO 9117147 . |
Extended Information