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【结 构 式】 
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【药物名称】GR-891 【化学名称】5-Fluoro-1-[3-(2-hydroxyethoxy)-1-(isopropoxy)propyl]pyrimidine-2,4(1H,3H)-dione 【CA登记号】138969-77-4 (undefined isomer) 【 分 子 式 】C12H19FN2O5 【 分 子 量 】290.29403 |
【开发单位】Universidad de Granada (Originator) 【药理作用】Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems, Antimetabolites |
合成路线1
By reaction of 5-isopropoxy-1,4-dioxepane (I) with 5-fluorouracil (II) by means of SnCl4, hexamethyldisilazane (HMDS) and trimethylchlorosilane (TCS) in acetonitrile.
| 【1】 Gallo, M.A.; et al.; A facile synthetic method for pyrimidine acyclonucleoside analogues from alkoxy-1,4-diheterocycloheptanes. Synlett 1993, 6, 389. |
| 【2】 Campos, J.; et al.; Diheterocyclanes as synthons for the preparation of novel series of nucleoside and acyclonucleoside analogues. Farmaco 1997, 52, 5, 263. |
| 【3】 Campos Rosa, J.; Gallo Mezo, M.A.; Dominguez Senglar, J.F.; Entrena Guadix, A.; Pineda de las Infantas y Villatoro, M.J.; Camacho Quesada, E.; Espinosa Ubeda, A. (Universidad de Granada); New uracil derivs. having an anti-tumour activity and related cpds. (N-1 derivs. of 5-substd.-uracile). WO 9117147 . |
Extended Information