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【结 构 式】 
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【分子编号】29210 【品名】chloroformamidine 【CA登记号】 |
【 分 子 式 】CH3ClN2 【 分 子 量 】78.501 【元素组成】C 15.3% H 3.85% Cl 45.16% N 35.69% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)2,6-Dichloropyridine (I) was nitrated with HNO3 and H2SO4 to give nitropyridine (II). Substitution of the 2-chloro atom of (II) with cuprous cyanide at 180 C afforded nitrile (III). The remaining 6-chloro atom of (III) was then substituted with N-methyl-3,4-dimethoxyaniline (IV) in monoethyl glycol in the presence of pyridine to provide diaryl amine (V). The nitro group of (V) was further reduced with iron powder and HCl yielding the 3-amino derivative (VI). Finally, cyclization of (VI) with chloroformamidine hydrochloride (VII) in dimethylsulfone at 140 C produced the target pyridopyrimidine.
| 【1】 Gangjee, A.; Zhu, Y.; Queener, S.F.; 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents. J Med Chem 1998, 41, 23, 4533. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13573 | 2,6-Dichloropyridine | 2402-78-0 | C5H3Cl2N | 详情 | 详情 |
| (II) | 13574 | 2,6-Dichloro-3-nitropyridine | 16013-85-7 | C5H2Cl2N2O2 | 详情 | 详情 |
| (III) | 29206 | 6-chloro-3-nitro-2-pyridinecarbonitrile | C6H2ClN3O2 | 详情 | 详情 | |
| (IV) | 29207 | 3,4-dimethoxy-N-methylaniline | C9H13NO2 | 详情 | 详情 | |
| (V) | 29208 | 6-[3,4-dimethoxy(methyl)anilino]-3-nitro-2-pyridinecarbonitrile | C15H14N4O4 | 详情 | 详情 | |
| (VI) | 29209 | 3-amino-6-[3,4-dimethoxy(methyl)anilino]-2-pyridinecarbonitrile | C15H16N4O2 | 详情 | 详情 | |
| (VII) | 29210 | chloroformamidine | CH3ClN2 | 详情 | 详情 |
Extended Information