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【结 构 式】 
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【分子编号】29127 【品名】2-bromobutane 【CA登记号】78-76-2 |
【 分 子 式 】C4H9Br 【 分 子 量 】137.01946 【元素组成】C 35.06% H 6.62% Br 58.32% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)The reaction of (IX) with hydrazine is converted to the hydrazinecarboxamide (X). The cyclization of (X) with formamidine (XI) in hot DMF yields the substituted triazolone (XII), which is finally alkylated with 2-bromobutane (XIII) and KOH in DMSO.
| 【1】 Van Cutsem, J.; Backx, L.J.J.; Heeres, J.; J. Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones. J Med Chem 1984, 27, 7, 894-900. |
| 【2】 Castaner, J.; Serradell, M.N.; Fromtling, R.A.; Itraconazole. Drugs Fut 1985, 10, 4, 291. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 29124 | phenyl 4-[4-(4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl)-1-piperazinyl]phenylcarbamate | C36H34Cl2N6O5 | 详情 | 详情 | |
| (X) | 29125 | N-[4-[4-(4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl)-1-piperazinyl]phenyl]-1-hydrazinecarboxamide | C30H32Cl2N8O4 | 详情 | 详情 | |
| (XI) | 15369 | Iminoformamide; Methanimidamide | 463-52-5 | CH4N2 | 详情 | 详情 |
| (XII) | 29126 | 4-[4-[4-(4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl)-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one | C31H30Cl2N8O4 | 详情 | 详情 | |
| (XIII) | 29127 | 2-bromobutane | 78-76-2 | C4H9Br | 详情 | 详情 |
Extended Information