|
【结 构 式】 
|
【分子编号】29117 【品名】[(2R,3R,4S,5R)-3-(acetoxy)-4-fluoro-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl benzoate 【CA登记号】 |
【 分 子 式 】C19H19FN2O7 【 分 子 量 】406.3675432 【元素组成】C 56.16% H 4.71% F 4.68% N 6.89% O 27.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)FMAU is prepared by condensation of 3-O-benzoyl-2-fluoro-D-arabinosyl bromide (I) with trimethylsilylated thymine (II) followed by saponification of the protected nucleoside (III).
| 【1】 Lopez, C.; Reichman, U.; Fox, J.; Hirota, K.; Watanabe, K.A.; Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides. J Med Chem 1979, 22, 1, 21-24. |
| 【2】 Lopez, C.; Klein, R.S.; Su, T.L.; Fox, J.J.; Watanabe, K.A.; Matsuda, A.; Chun, M.W.; Chun, C.K.; Nucleosides. 123. Synthesis of sntiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-beta-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships. J Med Chem 1983, 28, 2, 152-156. |
| 【3】 Lopez, C.; FMAU. Drugs Fut 1985, 10, 4, 288. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29116 | [(2R,3R,4S,5S)-3-(acetoxy)-5-bromo-4-fluorotetrahydro-2-furanyl]methyl benzoate | C14H14BrFO5 | 详情 | 详情 | |
| (II) | 12218 | 5-Methyl-2,4-bis[(trimethylsilyl)methyl]pyrimidine | C13H26N2Si2 | 详情 | 详情 | |
| (III) | 29117 | [(2R,3R,4S,5R)-3-(acetoxy)-4-fluoro-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl benzoate | C19H19FN2O7 | 详情 | 详情 |
Extended Information