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【结 构 式】

【分子编号】29039

【品名】4-(chlorocarbonyl)-2-methoxyphenyl ethyl carbonate

【CA登记号】

【 分 子 式 】C11H11ClO5

【 分 子 量 】258.65804

【元素组成】C 51.08% H 4.29% Cl 13.71% O 30.93%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The acylation of 2,4-dibromo-6-(N-cyclohexyl-N-methylaminomethyl)aniline (I) with 4-(ethoxycarbonyloxy)-3-methoxybenzoyl chloride (II) in CHCl3 gives the corresponding amide (III), which is deprotected by a treatment with aqueous 20% NaOH.

1 Koshinaka, E.; Ogawa, N.; Kurata, S.; Yamagashi, K.; Kato, I. (Hokuriku Seiyaku Co., Ltd.); 2-Benzoylamino substituted benzylamine derivative and a process for preparation thereof. DE 3209970; EP 0061157; ES 510608 .
2 Chu, S.S.; BR-227. Drugs Fut 1985, 10, 3, 186.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28174 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline C14H20Br2N2 详情 详情
(II) 29039 4-(chlorocarbonyl)-2-methoxyphenyl ethyl carbonate C11H11ClO5 详情 详情
(III) 29040 4-[(2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]anilino)carbonyl]-2-methoxyphenyl ethyl carbonate C25H30Br2N2O5 详情 详情
Extended Information