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【结 构 式】 
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【分子编号】28982 【品名】(4aR,6R,7R,7aR)-6-[6-(butyrylamino)-9H-purin-9-yl]-2-hydroxy-2-oxotetrahydro-4H-2lambda(5)-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butyrate 【CA登记号】 |
【 分 子 式 】C18H24N5O8P 【 分 子 量 】469.391222 【元素组成】C 46.06% H 5.15% N 14.92% O 27.27% P 6.6% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The reaction of adenosine-3',5'-cyclic phosphate (I) with butyric anhydride (II) in the presence of triethylamine gives N6,2'-O-dibutyryladenosine-3',5'-cyclic phosphate (III), which is then treated with Na-type Amberlite IR-120 B.
| 【1】 JP 76113896 . |
| 【2】 Hirayama, T.; et al.; Improved methods of producing adenosine derivatives. JP 52039699 . |
| 【3】 JP 76095096 . |
| 【4】 Castaner, J.; Serradell, M.N.; Bucladesine Sodium. Drugs Fut 1985, 10, 2, 106. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28980 | (4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-2lambda(5)-furo[3,2-d][1,3,2]dioxaphosphinin-2-one | 60-92-4 | C10H12N5O6P | 详情 | 详情 |
| (II) | 28981 | 1-propoxypropane | 111-43-3 | C6H14O | 详情 | 详情 |
| (III) | 28982 | (4aR,6R,7R,7aR)-6-[6-(butyrylamino)-9H-purin-9-yl]-2-hydroxy-2-oxotetrahydro-4H-2lambda(5)-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butyrate | C18H24N5O8P | 详情 | 详情 |
Extended Information