Bucladesine sodium, DT-5621, DBcAMP.Na, Actosin, -Drug Synthesis Database

【结构式】

【药物名称】Bucladesine sodium, DT-5621, DBcAMP.Na, Actosin

【化学名称】N-(1-Oxobutyl)adenosine cyclic 3',5'-(hydrogen phosphate) 2'-butanoate sodium salt

【CA登记号】19436-29-4, 362-74-3 (free acid), 16980-89-5 (monoNa salt)

【分子式】C₁₈H₂₃N₅NaO₈P

【分子量】491.37631

【开发单位】Daiichi Pharmaceutical (Originator)

【药理作用】DERMATOLOGIC DRUGS, Wound-Healing Agents

合成路线1

The reaction of adenosine-3',5'-cyclic phosphate (I) with butyric anhydride (II) in the presence of triethylamine gives N6,2'-O-dibutyryladenosine-3',5'-cyclic phosphate (III), which is then treated with Na-type Amberlite IR-120 B.

参考文献中间体

【1】 JP 76113896 .
【2】 Hirayama, T.; et al.; Improved methods of producing adenosine derivatives. JP 52039699 .
【3】 JP 76095096 .
【4】 Castaner, J.; Serradell, M.N.; Bucladesine Sodium. Drugs Fut 1985, 10, 2, 106.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28980	(4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-2lambda(5)-furo[3,2-d][1,3,2]dioxaphosphinin-2-one	60-92-4	C₁₀H₁₂N₅O₆P	详情	详情
(II)	28981	1-propoxypropane	111-43-3	C₆H₁₄O	详情	详情
(III)	28982	(4aR,6R,7R,7aR)-6-[6-(butyrylamino)-9H-purin-9-yl]-2-hydroxy-2-oxotetrahydro-4H-2lambda(5)-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butyrate		C₁₈H₂₄N₅O₈P	详情	详情

Extended Information