合成路线1

The reaction of 2-acetamido-5-hydroxypyridine (I) with (S)-glycidol 3-nitrobenzenesulfonate (II) by means of NaOH in DMF gives 2(S)-(6-acetamido-3-pyridyloxymethyl)oxirane (III), which is condensed with 2-(4-nitrophenyl)ethylamine (IV) by means of triethylamine in refluxing methanol yielding the chiral isopropanol (V). The protection of the secondary amino group of (V) with tert-butoxycarbonyl anhydride affords the carbamate (VI), which is submitted to reduction at the nitro group with H2 over Pd/C in ethyl acetate providing the aniline derivative (VII). The acylation of (VII) with 4-iodobenzenesulfonyl chloride (VIII) and pyridine in dichloromethane affords the sulfonamide (IX), which is finally deprotected with 2N HCl in refluxing methanol.