3-amino-6-(2,3-dichlorophenyl)-2-isopropyl-2,3-dihydro-1,2,4-triazin-5-ylamine -Drug Synthesis Database

【结构式】

【分子编号】28843

【品名】3-amino-6-(2,3-dichlorophenyl)-2-isopropyl-2,3-dihydro-1,2,4-triazin-5-ylamine

【CA登记号】

【分子式】C₁₂H₁₃Cl₂N₅

【分子量】298.17432

【元素组成】C 48.34% H 4.39% Cl 23.78% N 23.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) (I) is alkylated with 2-iodopropane in refluxing pentan-2-one. The free base, obtained following treatment of the hydroiodide with methanolic sodium hydroxide, is converted to the title compound with methanolic hydrogen chloride.

参考文献中间体

合成目标

【1】 Miller, A.A.; Allan, G.; Sawyer, D.A. (Glaxo Wellcome plc); 1,2,4-Triazines. EP 0142306; ES 8606304; JP 1985109577; US 4649139 .
【2】 Donoghue, S.; Sawyer, D.; Allan, G.; BW-A256C. Drugs Fut 1987, 12, 7, 621.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28842	3-amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5-ylamine		C₉H₇Cl₂N₅	详情	详情
(II)	19369	2-iodopropane	75-30-9	C₃H₇I	详情	详情
(III)	28843	3-amino-6-(2,3-dichlorophenyl)-2-isopropyl-2,3-dihydro-1,2,4-triazin-5-ylamine		C₁₂H₁₃Cl₂N₅	详情	详情

Extended Information