【结 构 式】 |
【分子编号】28842 【品名】3-amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5-ylamine 【CA登记号】 |
【 分 子 式 】C9H7Cl2N5 【 分 子 量 】256.09368 【元素组成】C 42.21% H 2.76% Cl 27.69% N 27.35% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) (I) is alkylated with 2-iodopropane in refluxing pentan-2-one. The free base, obtained following treatment of the hydroiodide with methanolic sodium hydroxide, is converted to the title compound with methanolic hydrogen chloride.
【1】 Miller, A.A.; Allan, G.; Sawyer, D.A. (Glaxo Wellcome plc); 1,2,4-Triazines. EP 0142306; ES 8606304; JP 1985109577; US 4649139 . |
【2】 Donoghue, S.; Sawyer, D.; Allan, G.; BW-A256C. Drugs Fut 1987, 12, 7, 621. |
Extended Information